First-of-its-kind treatment for Acute Lymphoblastic Leukemia developed

Tata Memorial, IDRS Labs develop an oral suspension to be available soon

geetanjali

Geetanjali Minhas | December 29, 2023 | Mumbai


#Health   #Healthcare   #cancer  


Tata Memorial Hospital, Mumbai, the Advanced Centre for Training Research and Education in Cancer (ACTREC), Navi Mumbai along with IDRS Labs, Bangalore have developed an oral suspension of 6-mercaptopurine (6-MP) in India. 6-MP is a chemotherapy drug used in the treatment of acute lymphoblastic leukemia (ALL), the most common type of blood cancer afflicting children.

The first and only child-friendly formulation is available in the form of a powder for oral suspension, and marketed under the tradename ‘PREVALL’.

PREVALL can be reconstituted into 100 ml oral suspension at a concentration of 10mg/ml. It is available with a syringe and a press in bottle adapter (PIBA) for precise dosing tailored to the patient’s body weight or body surface area.

It has been approval by the Central Drugs Standard Control Organization (CDSCO) under the ministry of health and family welfare, government of India. Tata Memorial Centre and IDRS Labs jointly published the results of the clinical study that lead to regulatory approval in the scientific journal Pediatric Blood and Cancer recently.

PREVALL, the dry powder pharmaceutical suspension of 6-mercaptopurine, is a patented technology of IDRS Labs Private Limited and will be available in all major hospital pharmacies across the country very soon. Approximately 10,000 children in the age group of 1-10 years diagnosed with ALL are expected to benefit from PREVALL each year.

Dr. Vikram, Professor of Clinical Pharmacology, ACTREC, said that the powder for oral suspension is designed to ensure stability of the drug in hot/humid conditions and is quite distinct from the liquid formulation available elsewhere in the world.

Dr. Sudeep Gupta, Director, Tata Memorial Centre, Mumbai, said that TMC is committed to fostering innovation, citing the example of CAR-T cell therapy  which was also pioneered by TMC recently in a similar collaborative effort.

Dr. Ajit Kumar Mohanty, Secretary Department of Atomic Energy, and Chairman, Atomic Energy Commission, said the development is an outcome of the convergence of academia and industry interests to bridge the gap between unmet need and innovation in healthcare.
 

Comments

 

Other News

New Delhi’s Indo-Pacific strategy enters a new phase

India appears to be investing fresh dynamism in its Indo-Pacific strategy. At the time when the US, under president Donald Trump, has adopted a conciliatory approach towards China and has changed the name of America’s Indo-Pacific Command to just Pacific Command, India has quietly moved towards con

CAG flags major fiscal lapses in Maharashtra

Maharashtra`s fiscal management has come under sharp scrutiny after the Comptroller and Auditor General (CAG) of India, in its State Finances Audit Report for 2024-25, flagged significant budgetary inefficiencies, accounting irregularities, understatement of key fiscal indicators and widespread governanc

The health sector research we are not doing

Some neglect is loud. This kind is quiet. It sits in research never commissioned, data never collected, questions never asked. In South Asia, that quiet has let the region’s worst health problems stay understudied, underfunded, and out of sight of those who could act.  

Study flags accessibility and last-mile challenges on Mumbai Metro Aqua Line

Mumbai Metro Line 3 (Aqua Line), the city`s first fully underground metro corridor and one of its largest public transport investments, represents a major engineering achievement and has been widely welcomed by commuters. However, the overall commuter experience continues to be constrained by accessibili

Centre intensifies preparedness as El Niño threat looms

Amid uncertainty in the southwest monsoon due to the potential impact of El Niño, the government is addressing the situation with comprehensive preparedness, a clear strategy, and strong ground-level action. While challenges remain, the entire system has been activated in advance and is working proa

India is crossing a climate threshold

On June 28, Delhi recorded a maximum temperature of 41.3°C, four degrees above the seasonal normal. But the “feels like” temperature, which factors in humidity, showed more than 51°C. What the body experienced was very different from what the thermometer recorded.  India`





Archives

Current Issue

Opinion

Facebook Twitter Google Plus Linkedin Subscribe Newsletter

Twitter